Article
A monoclonal antibody targeting a highly conserved epitope in influenza B neuraminidase provides protection against drug resistant strains.
Biochemical and biophysical research communications - 8 Nov 2013
Doyle Tracey M, Li Changgui, Bucher Doris J, Hashem Anwar M, Van Domselaar Gary, Wang Junzhi, Farnsworth Aaron, She Yi-Min, Cyr Terry, He Runtao, Brown Earl G, Hurt Aeron C, Li Xuguang
Abstract excerpt
All influenza viral neuraminidases (NA) of both type A and B viruses have only one universally conserved sequence located between amino acids 222-230. A monoclonal antibody against this region has been previously reported to provide broad inhibition against all nine subtypes of influenza A NA; yet its inhibitory effect against influenza B viral NA remained unknown. Here, we report that the monoclonal antibody...
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