Article
A highly conserved neutralizing epitope on group 2 influenza A viruses.
Science (New York, N.Y.) - 12 Aug 2011
Ekiert Damian C, Friesen Robert H E, Bhabha Gira, Kwaks Ted, Jongeneelen Mandy, Yu Wenli, Ophorst Carla, Cox Freek, Korse Hans J W M, Brandenburg Boerries, Vogels Ronald, Brakenhoff Just P J, Kompier Ronald, Koldijk Martin H, Cornelissen Lisette A H M, Poon Leo L M, Peiris Malik, Koudstaal Wouter, Wilson Ian A, Goudsmit Jaap
Abstract excerpt
Current flu vaccines provide only limited coverage against seasonal strains of influenza viruses. The identification of V(H)1-69 antibodies that broadly neutralize almost all influenza A group 1 viruses constituted a breakthrough in the influenza field. Here, we report the isolation and characterization of a human monoclonal antibody CR8020 with broad neutralizing activity against most group 2 viruses, including...
Topics
Join the communities discussing this publication.