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Article

Germline mutation in the RAD51B gene confers predisposition to breast cancer.

BMC cancer - 19 Oct 2013

Golmard Lisa, Caux-Moncoutier Virginie, Davy Grégoire, Al Ageeli Essam, Poirot Brigitte, Tirapo Carole, Michaux Dorothée, Barbaroux Catherine, d'Enghien Catherine Dubois, Nicolas André, Castéra Laurent, Sastre-Garau Xavier, Stern Marc-Henri, Houdayer Claude, Stoppa-Lyonnet Dominique

Abstract excerpt

BACKGROUND: Most currently known breast cancer predisposition genes play a role in DNA repair by homologous recombination. Recent studies conducted on RAD51 paralogs, involved in the same DNA repair pathway, have identified rare germline mutations conferring breast and/or ovarian cancer predisposition in the RAD51C, RAD51D and XRCC2 genes. The present study analysed the five RAD51 paralogs (RAD51B, RAD51C,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24139550
DOI: 10.1186/1471-2407-13-484
PMCID: PMC4016303

Genes

RAD51
XRCC2
XRCC3
BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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