Article
RAD51 and breast cancer susceptibility: no evidence for rare variant association in the Breast Cancer Family Registry study.
PloS one - 1 Jan 2012
Le Calvez-Kelm Florence, Oliver Javier, Damiola Francesca, Forey Nathalie, Robinot Nivonirina, Durand Geoffroy, Voegele Catherine, Vallée Maxime P, Byrnes Graham, Registry Breast Cancer Family, Hopper John L, Southey Melissa C, Andrulis Irene L, John Esther M, Tavtigian Sean V, Lesueur Fabienne
Abstract excerpt
BACKGROUND: Although inherited breast cancer has been associated with germline mutations in genes that are functionally involved in the DNA homologous recombination repair (HRR) pathway, including BRCA1, BRCA2, TP53, ATM, BRIP1, CHEK2 and PALB2, about 70% of breast cancer heritability remains une...
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