Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population.

doi:10.1200/JCO.2015.61.2408

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Article

Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Sept 2015

Song Honglin, Dicks Ed, Ramus Susan J, Tyrer Jonathan P, Intermaggio Maria P, Hayward Jane, Edlund Christopher K, Conti David, Harrington Patricia, Fraser Lindsay, Philpott Susan, Anderson Christopher, Rosenthal Adam, Gentry-Maharaj Aleksandra, Bowtell David D, Alsop Kathryn, Cicek Mine S, Cunningham Julie M, Fridley Brooke L, Alsop Jennifer, Jimenez-Linan Mercedes, Høgdall Estrid, Høgdall Claus K, Jensen Allan, Kjaer Susanne Krüger, Lubiński Jan, Huzarski Tomasz, Jakubowska Anna, Gronwald Jacek, Poblete Samantha, Lele Shashi, Sucheston-Campbell Lara, Moysich Kirsten B, Odunsi Kunle, Goode Ellen L, Menon Usha, Jacobs Ian J, Gayther Simon A, Pharoah Paul D P

Abstract excerpt

PURPOSE: The aim of this study was to estimate the contribution of deleterious mutations in the RAD51B, RAD51C, and RAD51D genes to invasive epithelial ovarian cancer (EOC) in the population and in a screening trial of individuals at high risk of ovarian cancer. PATIENTS AND METHODS: The coding sequence and splice site boundaries of the three RAD51 genes were sequenced and analyzed in germline DNA from a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26261251
DOI: 10.1200/JCO.2015.61.2408
PMCID: PMC4554751

Genes

RAD51
BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population.PMID 26261251Read ↗

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