Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of genetic variants that affect histone modifications in human cells.

Science (New York, N.Y.) - 8 Nov 2013

McVicker Graham, van de Geijn Bryce, Degner Jacob F, Cain Carolyn E, Banovich Nicholas E, Raj Anil, Lewellen Noah, Myrthil Marsha, Gilad Yoav, Pritchard Jonathan K

Abstract excerpt

Histone modifications are important markers of function and chromatin state, yet the DNA sequence elements that direct them to specific genomic locations are poorly understood. Here, we identify hundreds of quantitative trait loci, genome-wide, that affect histone modification or RNA polymerase II (Pol II) occupancy in Yoruba lymphoblastoid cell lines (LCLs). In many cases, the same variant is associated with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin

Share to Genome, Human

Share to Histones

Share to Protein Processing, Post-Translational

Share to Quantitative Trait Loci

Share to RNA Polymerase II

Source

Open in PubMed Open full text

Identifiers

PMID: 24136359
DOI: 10.1126/science.1242429
PMCID: PMC3947669

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of genetic variants that affect histone modifications in human cells.PMID 24136359Read ↗

RNA splicing is a primary link between genetic variation and disease.Semantic proximity Read ↗

Extensive variation in chromatin states across humans.Semantic proximity Read ↗

DNase I sensitivity QTLs are a major determinant of human expression variation.Semantic proximity Read ↗

Population Variation and Genetic Control of Modular Chromatin Architecture in Humans.Semantic proximity Read ↗

Methylation QTLs are associated with coordinated changes in transcription factor binding, histone modifications, and gene expression levels.Semantic proximity Read ↗

Genetic analyses support the contribution of mRNA N6-methyladenosine (m6A) modification to human disease heritability.Semantic proximity Read ↗

DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines.Semantic proximity Read ↗

Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription.Semantic proximity Read ↗

Genome-Wide Variation of Cytosine Modifications Between European and African Populations and the Implications for Complex TraitsSemantic proximity Read ↗

An integrated map of p53-binding sites and histone modification in the human ENCODE regionsSemantic proximity Read ↗

Enhancer histone-QTLs are enriched on autoimmune risk haplotypes and influence gene expression within chromatin networks.Semantic proximity Read ↗

Allele-specific chromatin immunoprecipitation studies show genetic influence on chromatin state in human genome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.