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Article

Methylation QTLs are associated with coordinated changes in transcription factor binding, histone modifications, and gene expression levels.

PLoS genetics - 1 Sept 2014

Banovich Nicholas E, Lan Xun, McVicker Graham, van de Geijn Bryce, Degner Jacob F, Blischak John D, Roux Julien, Pritchard Jonathan K, Gilad Yoav

Abstract excerpt

DNA methylation is an important epigenetic regulator of gene expression. Recent studies have revealed widespread associations between genetic variation and methylation levels. However, the mechanistic links between genetic variation and methylation remain unclear. To begin addressing this gap, we collected methylation data at ∼300,000 loci in lymphoblastoid cell lines (LCLs) from 64 HapMap Yoruba individuals, and...

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PMID: 25233095
DOI: 10.1371/journal.pgen.1004663
PMCID: PMC4169251

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