Article
DNase I sensitivity QTLs are a major determinant of human expression variation.
Nature - 5 Feb 2012
Degner Jacob F, Pai Athma A, Pique-Regi Roger, Veyrieras Jean-Baptiste, Gaffney Daniel J, Pickrell Joseph K, De Leon Sherryl, Michelini Katelyn, Lewellen Noah, Crawford Gregory E, Stephens Matthew, Gilad Yoav, Pritchard Jonathan K
Abstract excerpt
The mapping of expression quantitative trait loci (eQTLs) has emerged as an important tool for linking genetic variation to changes in gene regulation. However, it remains difficult to identify the causal variants underlying eQTLs, and little is known about the regulatory mechanisms by which they act. Here we show that genetic variants that modify chromatin accessibility and transcription factor binding are a...
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