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Article

Genetic analyses support the contribution of mRNA N6-methyladenosine (m6A) modification to human disease heritability.

Nature genetics - 1 Sept 2020

Zhang Zijie, Luo Kaixuan, Zou Zhongyu, Qiu Maguanyun, Tian Jiakun, Sieh Laura, Shi Hailing, Zou Yuxin, Wang Gao, Morrison Jean, Zhu Allen C, Qiao Min, Li Zhongshan, Stephens Matthew, He Xin, He Chuan

Abstract excerpt

N6-methyladenosine (m6A) plays important roles in regulating messenger RNA processing. Despite rapid progress in this field, little is known about the genetic determinants of m6A modification and their role in common diseases. In this study, we mapped the quantitative trait loci (QTLs) of m6A peaks in 60 Yoruba (YRI) lymphoblastoid cell lines. We found that m6A QTLs are largely independent of expression and...

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Identifiers

PMID: 32601472
DOI: 10.1038/s41588-020-0644-z
PMCID: PMC7483307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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