Article
Heritable individual-specific and allele-specific chromatin signatures in humans.
Science (New York, N.Y.) - 9 Apr 2010
McDaniell Ryan, Lee Bum-Kyu, Song Lingyun, Liu Zheng, Boyle Alan P, Erdos Michael R, Scott Laura J, Morken Mario A, Kucera Katerina S, Battenhouse Anna, Keefe Damian, Collins Francis S, Willard Huntington F, Lieb Jason D, Furey Terrence S, Crawford Gregory E, Iyer Vishwanath R, Birney Ewan
Abstract excerpt
The extent to which variation in chromatin structure and transcription factor binding may influence gene expression, and thus underlie or contribute to variation in phenotype, is unknown. To address this question, we cataloged both individual-to-individual variation and differences between homologous chromosomes within the same individual (allele-specific variation) in chromatin structure and transcription factor...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.