Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DICER1 hotspot mutations in non-epithelial gonadal tumours.

British journal of cancer - 12 Nov 2013

Witkowski L, Mattina J, Schönberger S, Murray M J, Choong C S, Huntsman D G, Reis-Filho J S, McCluggage W G, Nicholson J C, Coleman N, Calaminus G, Schneider D T, Arseneau J, Stewart C J R, Foulkes W D

Abstract excerpt

BACKGROUND: Non-epithelial gonadal tumours largely comprise sex cord-stromal tumours (SCSTs) and germ cell tumours (GCTs). Specific somatic mutations in DICER1, a microRNA maturation pathway gene, have been identified in these tumours. We conducted a study that aimed to confirm, refine and extend the previous observations. METHODS: We used Sanger sequencing to sequence the RNase IIIa and IIIb domains of DICER1 in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DEAD-box RNA Helicases
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infant

Share to Infant, Newborn

Share to Neoplasms, Germ Cell and Embryonal

Share to Ovarian Neoplasms

Share to Ribonuclease III

Share to Testicular Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 24136150
DOI: 10.1038/bjc.2013.637
PMCID: PMC3833222

Genes

DICER1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DICER1 hotspot mutations in non-epithelial gonadal tumours.PMID 24136150Read ↗

[Ovarian Sertoli-Leydig cell tumors: DICER1 hotspot mutations and associated clinicopathological features].Semantic proximity Read ↗

A survey of DICER1 hotspot mutations in ovarian and testicular sex cord-stromal tumors.Semantic proximity Read ↗

Spectrum of DICER1 Germline Pathogenic Variants in Ovarian Sertoli–Leydig Cell TumorSemantic proximity Read ↗

DICER1 RNase IIIb domain mutations are infrequent in testicular germ cell tumours.Semantic proximity Read ↗

DICER1 hot-spot mutations in ovarian gynandroblastoma.Semantic proximity Read ↗

Detection of the DICER1 hotspot mutation alongside immunohistochemical analysis may provide a better diagnostic measure for ovarian Sertoli-Leydig cell tumors.Semantic proximity Read ↗

Review on Sertoli-Leydig Cell Tumours of the Ovary.Semantic proximity Read ↗

DICER1-related Sertoli-Leydig cell tumor and gynandroblastoma: Clinical and genetic findings from the International Ovarian and Testicular Stromal Tumor Registry.Semantic proximity Read ↗

DICER1 Mutations Are Consistently Present in Moderately and Poorly Differentiated Sertoli-Leydig Cell Tumors.Semantic proximity Read ↗

Clinical Characteristics and Mutation Analyses of Ovarian Sertoli-Leydig Cell Tumors.Semantic proximity Read ↗

Sertoli-Leydig tumor and DICER1 gene mutation: A case series and literature review.Semantic proximity Read ↗

Evaluation of DICER1 Immunohistochemistry as a Potential Surrogate for Mutation Status in Ovarian Sex Cord-Stromal Tumors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.