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Article

A survey of DICER1 hotspot mutations in ovarian and testicular sex cord-stromal tumors.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 2015

Conlon Niamh, Schultheis Anne M, Piscuoglio Salvatore, Silva Annacarolina, Guerra Esther, Tornos Carmen, Reuter Victor E, Soslow Robert A, Young Robert H, Oliva Esther, Weigelt Britta

Abstract excerpt

Sertoli-Leydig cell tumors are characterized by the presence of somatic DICER1 hotspot mutations. In this study, we sought to define the association between DICER1 hotspot mutations and different morphologic subtypes of ovarian Sertoli-Leydig cell tumors. Furthermore, we aimed to assess whether DICER1 hotspot mutations occur in other ovarian sex cord-stromal tumors, testicular sex cord-stromal tumors, or other...

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Share to Cell Transformation, Neoplastic
Share to DEAD-box RNA Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to Microdissection

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Share to Reverse Transcriptase Polymerase Chain Reaction

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Source

Open in PubMed Open full text

Identifiers

PMID: 26428316
DOI: 10.1038/modpathol.2015.115
PMCID: PMC4666775

Genes

DICER1
FOXL2

Variants

Provenance

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A survey of DICER1 hotspot mutations in ovarian and testicular sex cord-stromal tumors.PMID 26428316Read ↗

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