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Article

DICER1 Mutations Are Consistently Present in Moderately and Poorly Differentiated Sertoli-Leydig Cell Tumors.

The American journal of surgical pathology - 1 Sept 2017

de Kock Leanne, Terzic Tatjana, McCluggage W Glenn, Stewart Colin J R, Shaw Patricia, Foulkes William D, Clarke Blaise A

Abstract excerpt

Ovarian Sertoli-Leydig cell tumors (SLCTs) are uncommon sex cord-stromal tumors associated with both germ-line and somatic DICER1 mutations, the frequency of which has varied widely in different studies (0% to 62.5%). The current World Health Organization Classification includes 3 histologic types of SLCTs (well-differentiated, moderately differentiated, and poorly differentiated); heterologous elements and/or...

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Identifiers

PMID: 28654427
DOI: 10.1097/PAS.0000000000000895

Genes

DICER1

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DICER1 Mutations Are Consistently Present in Moderately and Poorly Differentiated Sertoli-Leydig Cell Tumors.PMID 28654427Read ↗

Well-differentiated Sertoli-Leydig Cell Tumors (SLCTs) Are Not Associated With DICER1 Pathogenic Variants and Represent a Different Tumor Type to Moderately and Poorly Differentiated SLCTs.Semantic proximity Read ↗

Detection of the DICER1 hotspot mutation alongside immunohistochemical analysis may provide a better diagnostic measure for ovarian Sertoli-Leydig cell tumors.Semantic proximity Read ↗

Evaluation of DICER1 Immunohistochemistry as a Potential Surrogate for Mutation Status in Ovarian Sex Cord-Stromal Tumors.Semantic proximity Read ↗

DICER1 and FOXL2 Mutation Status Correlates With Clinicopathologic Features in Ovarian Sertoli-Leydig Cell TumorsSemantic proximity Read ↗

Review on Sertoli-Leydig Cell Tumours of the Ovary.Semantic proximity Read ↗

[Ovarian Sertoli-Leydig cell tumors: DICER1 hotspot mutations and associated clinicopathological features].Semantic proximity Read ↗

Spectrum of DICER1 Germline Pathogenic Variants in Ovarian Sertoli–Leydig Cell TumorSemantic proximity Read ↗

Clinical Characteristics and Mutation Analyses of Ovarian Sertoli-Leydig Cell Tumors.Semantic proximity Read ↗

Prognostic Significance of Germline DICER1 Pathogenic or Likely Pathogenic Variants in Outcomes of Ovarian Sertoli-Leydig Cell TumorSemantic proximity Read ↗

Ovarian Sex Cord-Stromal Tumors in Patients With Probable or Confirmed Germline DICER1 MutationsSemantic proximity Read ↗

Pediatric Sertoli-Leydig Cell Tumors of the Ovary: An Integrated Study of Clinicopathological Features, Pan-cancer-Targeted Next-generation Sequencing and Chromosomal Microarray Analysis From a Single Institution.Semantic proximity Read ↗

A survey of DICER1 hotspot mutations in ovarian and testicular sex cord-stromal tumors.Semantic proximity Read ↗

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