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Article

Glycosyl phosphatidylinositol anchor biosynthesis is essential for maintaining epithelial integrity during Caenorhabditis elegans embryogenesis.

PLoS genetics - 1 Mar 2015

Budirahardja Yemima, Doan Thang Dinh, Zaidel-Bar Ronen

Abstract excerpt

Glycosylphosphatidylinositol (GPI) is a post-translational modification resulting in the attachment of modified proteins to the outer leaflet of the plasma membrane. Tissue culture experiments have shown GPI-anchored proteins (GPI-APs) to be targeted to the apical membrane of epithelial cells. However, the in vivo importance of this targeting has not been investigated since null mutations in GPI biosynthesis...

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Source

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Identifiers

PMID: 25807459
DOI: 10.1371/journal.pgen.1005082
PMCID: PMC4373761

Genes

GPI
PIGV

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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