Article
Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice.
Proceedings of the National Academy of Sciences of the United States of America - 31 Jul 2012
Brandl Katharina, Tomisato Wataru, Li Xiaohong, Neppl Christina, Pirie Elaine, Falk Werner, Xia Yu, Moresco Eva Marie Y, Baccala Roberto, Theofilopoulos Argyrios N, Schnabl Bernd, Beutler Bruce
Abstract excerpt
Using an environmentally sensitized genetic screen we identified mutations that cause inflammatory colitis in mice. The X-linked Klein-Zschocher (KLZ) mutation created a null allele of Yipf6, a member of a gene family believed to regulate vesicular transport in yeast, but without known functions in mammals. Yipf6 is a five transmembrane-spanning protein associated with Golgi compartments. Klein-Zschocher mutants...
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