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Article

Residues Arg703, Asp777, and Arg781 of the RNase H domain of hepatitis B virus polymerase are critical for viral DNA synthesis.

Journal of virology - 1 Jan 2014

Ko Chunkyu, Shin Youn-Chul, Park Woo-Jin, Kim Seungtaek, Kim Jonghwa, Ryu Wang-Shick

Abstract excerpt

Hepatitis B virus (HBV) synthesizes its DNA genome through reverse transcription, which is catalyzed by viral polymerase (Pol). Previous studies suggested that the RNase H domain of hepadnaviral Pol may contribute to multiple steps of the viral genome replication, such as RNA encapsidation and viral DNA synthesis. However, specific residues of the RNase H domain that contribute to viral reverse transcription have...

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Identifiers

PMID: 24131721
DOI: 10.1128/JVI.01916-13
PMCID: PMC3911735

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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