Article
Identification of a structural element of the hepatitis C virus minus strand RNA involved in the initiation of RNA synthesis.
Nucleic acids research - 1 Jul 2010
Mahias Kathleen, Ahmed-El-Sayed Neveen, Masante Cyril, Bitard Juliette, Staedel Cathy, Darfeuille Fabien, Ventura Michel, Astier-Gin Thérèse
Abstract excerpt
The replication of the genomic RNA of the hepatitis C virus (HCV) of positive polarity involves the synthesis of a replication intermediate of negative polarity by the viral RNA-dependent RNA polymerase (NS5B). In vitro and likely in vivo, the NS5B initiates RNA synthesis without primers. This de novo mechanism needs specific interactions between the polymerase and viral RNA elements. Cis-acting elements involved...
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