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Article

Effects of insertional and point mutations on the functions of the duck hepatitis B virus polymerase

1 Nov 1990

Abstract excerpt

The polymerase (P) gene of hepadnaviruses encodes a large polypeptide that appears to participate in several steps in the viral life cycle: packaging of viral RNA, providing the primer for synthesis of minus-strand DNA, synthesizing minus-strand DNA from an RNA template and plus-strand DNA from a DNA template, and degrading viral RNA in RNA-DNA hybrids. To assist in the assignment of these functions to domains of...

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Identifiers

PMID: 1698997
DOI: 10.1128/jvi.64.11.5553-5558.1990

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Effects of insertional and point mutations on the functions of the duck hepatitis B virus polymerasePMID 1698997Read ↗

Selected mutations of the duck hepatitis B virus P gene RNase H domain affect both RNA packaging and priming of minus-strand DNA synthesisSemantic proximity Read ↗

Naturally occurring point mutation in the C terminus of the polymerase gene prevents duck hepatitis B virus RNA packaging.Semantic proximity Read ↗

Mutational analysis of the hepatitis B virus P gene product: domain structure and RNase H activity.Semantic proximity Read ↗

Predicted structure of the hepatitis B virus polymerase reveals an ancient conserved protein foldSemantic proximity Read ↗

A domain of the hepadnavirus capsid protein is specifically required for DNA maturation and virus assembly.Semantic proximity Read ↗

Polymerase gene products of hepatitis B viruses are required for genomic RNA packaging as wel as for reverse transcription.Semantic proximity Read ↗

Evidence that less-than-full-length pol gene products are functional in hepadnavirus DNA synthesis.Semantic proximity Read ↗

Residues Arg703, Asp777, and Arg781 of the RNase H domain of hepatitis B virus polymerase are critical for viral DNA synthesis.Semantic proximity Read ↗

Evidence that the first strand-transfer reaction of duck hepatitis B virus reverse transcription requires the polymerase and that strand transfer is not needed for the switch of the polymerase to the elongation mode of DNA synthesis.Semantic proximity Read ↗

Hepatitis B virus nucleocapsids formed by carboxy-terminally mutated core proteins contain spliced viral genomes but lack full-size DNA.Semantic proximity Read ↗

Mapping of Functional Subdomains in the Terminal Protein Domain of Hepatitis B Virus Polymerase.Semantic proximity Read ↗

dNTP versus NTP discrimination by phenylalanine 451 in duck hepatitis B virus P protein indicates a common structure of the dNTP-binding pocket with other reverse transcriptases.Semantic proximity Read ↗

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