Article
Impact of the common MTHFR 677C→T polymorphism on blood pressure in adulthood and role of riboflavin in modifying the genetic risk of hypertension: evidence from the JINGO project.
BMC medicine - 11 Nov 2020
Ward Mary, Hughes Catherine F, Strain J J, Reilly Rosie, Cunningham Conal, Molloy Anne M, Horigan Geraldine, Casey Miriam, McCarroll Kevin, O'Kane Maurice, Gibney Michael J, Flynn Albert, Walton Janette, McNulty Breige A, McCann Adrian, Kirwan Laura, Scott John M, McNulty Helene
Abstract excerpt
BACKGROUND: Genome-wide and clinical studies have linked the 677C→T polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR) with hypertension, whilst limited evidence shows that intervention with riboflavin (i.e. the MTHFR co-factor) can lower blood pressure (BP) in hypertensive patients with the variant MTHFR 677TT genotype. We investigated the impact of this common polymorphism on BP...
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