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Article

MTHFR 677C-->T mutation, folate intake, neural-tube defect, and risk of cardiovascular disease.

Lancet (London, England) - 30 Aug 1997

Wilcken D E

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Share to Coronary Disease
Share to Folic Acid
Share to Homozygote
Share to Methylenetetrahydrofolate Reductase (NADPH2)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neural Tube Defects

Share to Nutritional Physiological Phenomena

Share to Oxidoreductases Acting on CH-NH Group Donors

Source

Identifiers

PMID: 9288038
DOI: 10.1016/S0140-6736(05)63320-X

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

MTHFR 677C-->T mutation, folate intake, neural-tube defect, and risk of cardiovascular disease.PMID 9288038Read ↗

Acrania, MTHFR 677C-->T mutation and role of folate intake.Semantic proximity Read ↗

MTHFR Gene Polymorphisms: A Single Gene with Wide-Ranging Clinical ImplicationsSemantic proximity Read ↗

MTHFR Gene Polymorphisms: A Single Gene with Wide-Ranging Clinical Implications—A ReviewSemantic proximity Read ↗

Genetic variation in genes of folate metabolism and neural-tube defect risk.Semantic proximity Read ↗

The 677C→T variant of MTHFR is the major genetic modifier of biomarkers of folate status in a young, healthy Irish populationSemantic proximity Read ↗

"Polymorphisms in folate metabolism genes as maternal risk factor for neural tube defects: an updated meta-analysis".Semantic proximity Read ↗

Analysis of MTHFR 1298A>C in addition to MTHFR 677C>T polymorphism as a risk factor for neural tube defects in the Turkish population.Semantic proximity Read ↗

MTHFR 677C->T genotype is associated with folate and homocysteine concentrations in a large, population-based, double-blind trial of folic acid supplementation.Semantic proximity Read ↗

Association of the maternal MTHFR C677T polymorphism with susceptibility to neural tube defects in offsprings: evidence from 25 case-control studies.Semantic proximity Read ↗

Genetic variants in the folate pathway and the risk of neural tube defects: a meta-analysis of the published literature.Semantic proximity Read ↗

Methylenetetrahydrofolate (MTHFR), the One-Carbon Cycle, and Cardiovascular RisksSemantic proximity Read ↗

MTHFR 677TT genotype and disease risk: is there a modulating role for B-vitamins?Semantic proximity Read ↗

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