Article
Exploring the pathways to chronic lymphocytic leukemia.
Blood - 9 Sept 2021
Stevenson Freda K, Forconi Francesco, Kipps Thomas J
Abstract excerpt
In chronic lymphocytic leukemia (CLL), increasing knowledge of the biology of the tumor cells has led to transformative improvements in our capacity to assess and treat patients. The dependence of tumor cells on surface immunoglobulin receptor signaling, survival pathways, and accessory cells within the microenvironment has led to a successful double-barreled attack with designer drugs. Studies have revealed that...
Topics
- Animals
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell
- Mutation
- Neoplasm Proteins
- Receptors, Antigen, B-Cell
- Signal Transduction
- Tumor Microenvironment