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Article

Gender-dependent association of the functional catechol-O-methyltransferase Val158Met genotype with sensation seeking personality trait.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Sept 2007

Lang Undine E, Bajbouj Malek, Bajbouj Malck, Sander Thomas, Gallinat Juergen

Abstract excerpt

The gene encoding cathechol-O-methyltransferase (COMT) contains a common functional missense polymorphism (Val158Met) that regulates dopamine in an allele-dependent manner. A pivotal role of dopamine neurotransmission in the prefrontal cortex has been implicated in drug-seeking behavior and related personality traits, such as sensation seeking, with some evidence for a gender-specific association. Here, we tested...

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Source

Identifiers

PMID: 17299513
DOI: 10.1038/sj.npp.1301335

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Gender-dependent association of the functional catechol-O-methyltransferase Val158Met genotype with sensation seeking personality trait.PMID 17299513Read ↗

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