Article
An exploratory association of polymorphisms in angiogenesis-related genes with susceptibility, clinical response and toxicity in gastrointestinal stromal tumors receiving sunitinib after imatinib failure.
Angiogenesis - 1 Feb 2017
Ravegnini Gloria, Nannini Margherita, Zenesini Corrado, Simeon Vittorio, Sammarini Giulia, Urbini Milena, Gatto Lidia, Saponara Maristella, Biasco Guido, Pantaleo Maria A, Venturoli Nicola, Hrelia Patrizia, Angelini Sabrina
Abstract excerpt
The angiogenic pathway plays a pivotal role in tumor growth, invasiveness and metastasis. The most important actors in the angiogenic pathway are VEGFA and its receptors VEGFR1, 2 and 3. These genes are polymorphic, and the presence of single nucleotide polymorphisms may result in angiogenic deregulation. Herein, we hypothesized that germline variants may affect sunitinib efficacy (TTP and OS) and/or toxicity....
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