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PNPLA3 , the history of an orphan gene of the potato tuber protein family that found an organ: The liver

12 Oct 2013

Abstract excerpt

To fall in love is to create a religion that has a fallible god. — Jorge Luis Borges (1952) The patatin-like phospholipase domain containing 3 gene (PNPLA3) was an orphan gene looking for a disease until 2008 when the first genome-wide association study (GWAS) on nonalcoholic fatty liver disease (NAFLD) showed the association between the risk of liver fat accumulation and the nonsynonymous rs738409 C/G variant.1...

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PMID: 24122882
DOI: 10.1002/hep.26895

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