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Article

Slow Misfolding of a Molten Globule form of a Mutant Prion Protein Variant into a β-rich Dimer.

Journal of molecular biology - 1 Oct 2024

Pal Suman, Udgaonkar Jayant B

Abstract excerpt

Misfolding of the prion protein is linked to multiple neurodegenerative diseases. A better understanding of the process requires the identification and structural characterization of intermediate conformations via which misfolding proceeds. In this study, three conserved aromatic residues (Tyr168, Phe174, and Tyr217) located in the C-terminal domain of mouse PrP (wt moPrP) were mutated to Ala. The resultant...

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Identifiers

PMID: 39097185
DOI: 10.1016/j.jmb.2024.168736

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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