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Article

Exposure of β6/β7-Loop in Zn/Cu Superoxide Dismutase (SOD1) Is Coupled to Metal Loss and Is Transiently Reversible During Misfolding.

ACS chemical neuroscience - 6 Jan 2021

Bakavayev Shamchal, Argueti Shirel, Venkatachalam Nachiyappan, Yehezkel Galit, Stavsky Alexandra, Barak Zeev, Israelson Adrian, Engel Stanislav

Abstract excerpt

Upon losing its structural integrity (misfolding), SOD1 acquires neurotoxic properties to become a pathogenic protein in ALS, a neurodegenerative disease targeting motor neurons; understanding the mechanism of misfolding may enable new treatment strategies for ALS. Here, we reported a monoclonal antibody, SE21, targeting the β6/β7-loop region of SOD1. The exposure of this region is coupled to metal loss and is...

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PMID: 33326235
DOI: 10.1021/acschemneuro.0c00524

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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