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Article

Probing early misfolding events in prion protein mutants by NMR spectroscopy.

Molecules (Basel, Switzerland) - 7 Aug 2013

Giachin Gabriele, Biljan Ivana, Ilc Gregor, Plavec Janez, Legname Giuseppe

Abstract excerpt

The post-translational conversion of the ubiquitously expressed cellular form of the prion protein, PrPC, into its misfolded and pathogenic isoform, known as prion or PrPSc, plays a key role in prion diseases. These maladies are denoted transmissible spongiform encephalopathies (TSEs) and affect both humans and animals. A prerequisite for understanding TSEs is unraveling the molecular mechanism leading to the...

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Identifiers

PMID: 23966072
DOI: 10.3390/molecules18089451
PMCID: PMC6270549

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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