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Article

Oxidative modification to cysteine sulfonic acid of Cys111 in human copper-zinc superoxide dismutase.

The Journal of biological chemistry - 7 Dec 2007

Fujiwara Noriko, Nakano Miyako, Kato Shinsuke, Yoshihara Daisaku, Ookawara Tomomi, Eguchi Hironobu, Taniguchi Naoyuki, Suzuki Keiichiro

Abstract excerpt

Copper-zinc superoxide dismutase (SOD1) plays a protective role against oxidative stress. On the other hand, recent studies suggest that SOD1 itself is a major target of oxidative damage and has its own pathogenicity in various neurodegenerative diseases, including familial amyotrophic lateral sclerosis. Only human and great ape SOD1s among mammals have the highly reactive free cysteine residue, Cys(111), at the...

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Source

Identifiers

PMID: 17913710
DOI: 10.1074/jbc.M702941200

Genes

SOD1
SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Oxidative modification to cysteine sulfonic acid of Cys111 in human copper-zinc superoxide dismutase.PMID 17913710Read ↗

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