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Article

Skin fragility and impaired desmosomal adhesion in mice lacking all keratins.

The Journal of investigative dermatology - 1 Apr 2014

Bär Janina, Kumar Vinod, Roth Wera, Schwarz Nicole, Richter Miriam, Leube Rudolf E, Magin Thomas M

Abstract excerpt

Keratins perform major structural and regulatory functions in epithelia. Owing to redundancy, their respective contribution to epidermal integrity, adhesion, and cell junction formation has not been addressed in full. Unexpectedly, the constitutive deletion of type II keratins in mice was embryonic lethal ∼ E9.5 without extensive tissue damage. This prompted us to analyze keratin functions in skin where keratins...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24121403
DOI: 10.1038/jid.2013.416

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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