Article
A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.
The Journal of cell biology - 7 Dec 2015
Kumar Vinod, Bouameur Jamal-Eddine, Bär Janina, Rice Robert H, Hornig-Do Hue-Tran, Roop Dennis R, Schwarz Nicole, Brodesser Susanne, Thiering Sören, Leube Rudolf E, Wiesner Rudolf J, Vijayaraj Preethi, Brazel Christina B, Heller Sandra, Binder Hans, Löffler-Wirth Henry, Seibel Peter, Magin Thomas M
Abstract excerpt
Keratin intermediate filaments (KIFs) protect the epidermis against mechanical force, support strong adhesion, help barrier formation, and regulate growth. The mechanisms by which type I and II keratins contribute to these functions remain incompletely understood. Here, we report that mice lacking all type I or type II keratins display severe barrier defects and fragile skin, leading to perinatal mortality with...
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