Article
Keratin transgenic and knockout mice: functional analysis and validation of disease-causing mutations.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2007
Vijayaraj Preethi, Söhl Goran, Magin Thomas M
Abstract excerpt
The intermediate filament (IF) cytoskeleton of mammalian epithelia is generated from pairs of type I and type II keratins that are encoded by two large gene families, made up of 54 genes in humans and the mouse. These genes are expressed in a spatiotemporal and tissue-specific manner from the blastocyst stage onward. Since the discovery of keratin mutations leading to epidermolysis bullosa simplex, mutations in...
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