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Article

PKM2 is not required for pancreatic ductal adenocarcinoma

23 Oct 2018

Abstract excerpt

While most cancer cells preferentially express the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2), PKM2 is dispensable for tumor development in several mouse cancer models. PKM2 is expressed in human pancreatic cancer, and there have been conflicting reports on the association of PKM2 expression and pancreatic cancer patient survival, but whether PKM2 is required for pancreatic cancer progression is...

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PMID: 30386596
DOI: 10.1186/s40170-018-0188-1

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