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Article

Novel simplified yeast-based assays of regulators of p53-MDMX interaction and p53 transcriptional activity.

The FEBS journal - 1 Dec 2013

Leão Mariana, Gomes Sara, Soares Joana, Bessa Cláudia, Maciel Cláudia, Ciribilli Yari, Pereira Clara, Inga Alberto, Saraiva Lucília

Abstract excerpt

Yeast has proven to be an efficient model system for functional and pharmacological studies of the p53 tumour suppressor protein. In this work, the human p53-MDMX regulatory pathway was reconstituted in yeast. Additionally, by using the known inhibitor of p53-MDMX interaction, SJ-172550, the efficacy of a simplified yeast-based screening assay to search for inhibitors of p53-MDMX interaction is demonstrated for...

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Identifiers

PMID: 24119020
DOI: 10.1111/febs.12552

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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