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Article

p53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening system.

PloS one - 1 Jan 2011

Andreotti Virginia, Ciribilli Yari, Monti Paola, Bisio Alessandra, Lion Mattia, Jordan Jennifer, Fronza Gilberto, Menichini Paola, Resnick Michael A, Inga Alberto

Abstract excerpt

BACKGROUND: The p53 tumor suppressor, which is altered in most cancers, is a sequence-specific transcription factor that is able to modulate the expression of many target genes and influence a variety of cellular pathways. Inactivation of the p53 pathway in cancer frequently occurs through the expression of mutant p53 protein. In tumors that retain wild type p53, the pathway can be altered by upstream modulators,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21674059
DOI: 10.1371/journal.pone.0020643
PMCID: PMC3107237

Genes

MDM2
MDM4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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