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Article

Improving Reporter Gene Assay Methodology for Evaluating the Ability of Compounds to Restore P53 Activity.

International journal of molecular sciences - 10 Nov 2022

Han Xinle, Du Jun, Shi Dandan, Li Lingjie, Li Dandan, Zhang Kun, Lin Suwen, Zhu Jingzhong, Huang Zoufang, Zhou You, Fang Zhengyu

Abstract excerpt

Tumor suppressor protein P53 induces cycle arrest and apoptosis by mediating the transcriptional expression of its target genes. Mutations causing conformational abnormalities and post-translational modifications that promote degradation are the main reasons for the loss of P53 function in tumor cells. Reporter gene assays that can scientifically reflect the biological function can help discover the mechanism and...

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Identifiers

PMID: 36430341
DOI: 10.3390/ijms232213867
PMCID: PMC9694221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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