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Article

Deranged epidermal differentiation in kl/kl mouse and the effects of βKlotho siRNA on the differentiation of HaCaT cells.

Experimental dermatology - 1 Nov 2013

Nakai Kozo, Yoneda Kozo, Haba Reiji, Kushida Yoshio, Katsuki Naomi, Moriue Tetsuya, Kosaka Hiroaki, Kubota Yasuo, Inoue Shigeaki

Abstract excerpt

Mice deficient in the klotho gene (kl/kl mice) display the phenotypes of human ageing. We found that the expression of epidermal differentiation-associated factors (keratin 1, keratin 10, filaggrin and loricrin) was lower in the skin of kl/kl mice than that of wild-type mice. In vitro experiments showed that the expression of βKlotho, a family of klotho gene-encoded protein, was induced concomitantly with the...

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Identifiers

PMID: 24118302
DOI: 10.1111/exd.12258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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