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Article

The combined effects of Map3k1 mutation and dioxin on differentiation of keratinocytes derived from mouse embryonic stem cells.

Scientific reports - 7 Jul 2022

Wang Jingjing, Xiao Bo, Kimura Eiki, Mongan Maureen, Xia Ying

Abstract excerpt

Epithelial development starts with stem cell commitment to ectoderm followed by differentiation to the basal keratinocytes. The basal keratinocytes, first committed in embryogenesis, constitute the basal layer of the epidermis. They have robust proliferation and differentiation potential and are responsible for epidermal expansion, maintenance and regeneration. We generated basal epithelial cells in vitro through...

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Identifiers

PMID: 35798792
DOI: 10.1038/s41598-022-15760-z
PMCID: PMC9263165

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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