Article
Deletion of the sequence encoding the tail domain of the bone morphogenetic protein type 2 receptor reveals a bone morphogenetic protein 7-specific gain of function.
PloS one - 1 Jan 2013
Leyton Patricio A, Beppu Hideyuki, Pappas Alexandra, Martyn Trejeeve M, Derwall Matthias, Baron David M, Galdos Rita, Bloch Donald B, Bloch Kenneth D
Abstract excerpt
The bone morphogenetic protein (BMP) type II receptor (BMPR2) has a long cytoplasmic tail domain whose function is incompletely elucidated. Mutations in the tail domain of BMPR2 are found in familial cases of pulmonary arterial hypertension. To investigate the role of the tail domain of BMPR2 in BMP signaling, we generated a mouse carrying a Bmpr2 allele encoding a non-sense mediated decay-resistant mutant...
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