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Article

Consequences of BMPR2 Deficiency in the Pulmonary Vasculature and Beyond: Contributions to Pulmonary Arterial Hypertension.

International journal of molecular sciences - 24 Aug 2018

Andruska Adam, Spiekerkoetter Edda

Abstract excerpt

Since its association with familial pulmonary arterial hypertension (PAH) in 2000, Bone Morphogenetic Protein Receptor II (BMPR2) and its related signaling pathway have become recognized as a key regulator of pulmonary vascular homeostasis. Herein, we define BMPR2 deficiency as either an inactivation of the receptor, decreased receptor expression, or an impairment of the receptor's downstream signaling pathway....

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Share to Bone Morphogenetic Protein Receptors, Type II
Share to Cardiovascular Physiological Phenomena

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiovascular System

Share to Familial Primary Pulmonary Hypertension

Share to Immune System

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Share to Pulmonary Artery

Source

Open in PubMed Open full text

Identifiers

PMID: 30149506
DOI: 10.3390/ijms19092499
PMCID: PMC6165502

Genes

BMPR2
PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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