Article
A single nucleotide polymorphism associated with hepatitis C virus infections located in the distal region of the IL28B promoter influences NF-κB-mediated gene transcription.
PloS one - 1 Jan 2013
Chinnaswamy Sreedhar, Chatterjee Snehajyoti, Boopathi Ramachandran, Mukherjee Shuvolina, Bhattacharjee Samsiddhi, Kundu Tapas K
Abstract excerpt
Persistence of hepatitis C virus (HCV) infection is observed only in a subset of infected individuals and among them only some respond to treatment. Genome-wide association studies (GWAS) carried out around the world identified single nucleotide polymorphisms (SNPs) in the IL28B locus that are strongly associated with both HCV clearance and treatment response. The functional significance of these associations...
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