Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C.

doi:10.1038/ng.449

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Article

Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C.

Nature genetics - 1 Oct 2009

Tanaka Yasuhito, Nishida Nao, Sugiyama Masaya, Kurosaki Masayuki, Matsuura Kentaro, Sakamoto Naoya, Nakagawa Mina, Korenaga Masaaki, Hino Keisuke, Hige Shuhei, Ito Yoshito, Mita Eiji, Tanaka Eiji, Mochida Satoshi, Murawaki Yoshikazu, Honda Masao, Sakai Akito, Hiasa Yoichi, Nishiguchi Shuhei, Koike Asako, Sakaida Isao, Imamura Masatoshi, Ito Kiyoaki, Yano Koji, Masaki Naohiko, Sugauchi Fuminaka, Izumi Namiki, Tokunaga Katsushi, Mizokami Masashi

Abstract excerpt

The recommended treatment for patients with chronic hepatitis C, pegylated interferon-alpha (PEG-IFN-alpha) plus ribavirin (RBV), does not provide sustained virologic response (SVR) in all patients. We report a genome-wide association study (GWAS) to null virological response (NVR) in the treatment of patients with hepatitis C virus (HCV) genotype 1 within a Japanese population. We found two SNPs near the gene...

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PMID: 19749757
DOI: 10.1038/ng.449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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