Article
Analysis of IL28B variants in an Egyptian population defines the 20 kilobases minimal region involved in spontaneous clearance of hepatitis C virus.
PloS one - 1 Jan 2012
Pedergnana Vincent, Abdel-Hamid Mohamed, Guergnon Julien, Mohsen Amira, Le Fouler Lénaïg, Theodorou Ioannis, Mohamed Mostafa Kamal, Fontanet Arnaud, Plancoulaine Sabine, Abel Laurent
Abstract excerpt
Spontaneous clearance of hepatitis C virus (HCV) occurs in ~30% of acute infections. Host genetics play a major role in HCV clearance, with a strong effect of single nucleotide polymorphisms (SNPs) of the IL28B gene already found in different populations, mostly infected with viral genotypes 1 and 3. Egypt has the highest prevalence of HCV infection in the world, which is mostly due to viral genotype 4. We...
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