Article
Single-cell analysis reveals early manifestation of cancerous phenotype in pre-malignant esophageal cells.
PloS one - 1 Jan 2013
Wang Jiangxin, Shi Xu, Johnson Roger H, Kelbauskas Laimonas, Zhang Weiwen, Meldrum Deirdre R
Abstract excerpt
Cellular heterogeneity plays a pivotal role in a variety of functional processes in vivo including carcinogenesis. However, our knowledge about cell-to-cell diversity and how differences in individual cells manifest in alterations at the population level remains very limited mainly due to the lack of appropriate tools enabling studies at the single-cell level. We present a study on changes in cellular...
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