Article

Filtering cells with high mitochondrial content removes viable metabolically altered malignant cell populations in cancer single-cell studies

2024-10-25

Abstract excerpt

<h4>Background</h4> Single-cell transcriptomics has transformed our understanding of cellular diversity in biological systems. However, systematic noise, often introduced by low-quality cells, can obscure biological signals if not properly accounted for. Thus, one of the common quality control steps involves filtering out cells with a high percentage of mitochondrial RNA counts (pctMT), as high pctMT typically in...

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Literature Corpus work: dd36f57d-c1a9-58ca-9ec9-0cfc199d133d
DOI: 10.1101/2024.10.24.620025

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