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Article

Effects of Microtubule Modulators on HIV-1 Infection of Transformed and Resting CD4 T Cells

6 Jan 2011

Abstract excerpt

Previous studies have observed fluorescently labeled HIV particles tracking along microtubule networks for nuclear localization. To provide direct evidence for the involvement of microtubules in early steps of HIV infection of human CD4 T cells, we used multiple microtubule modulators such as paclitaxel (originally called taxol; 1 μM), vinblastine (1 and 10 μM), colchicine (10 and 100 μM), and nocodazole (10 and...

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PMID: 21209111
DOI: 10.1128/jvi.02462-10

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