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Article

Caspase cleavage of GFAP produces an assembly-compromised proteolytic fragment that promotes filament aggregation.

ASN neuro - 19 Nov 2013

Chen Mei-Hsuan, Hagemann Tracy L, Quinlan Roy A, Messing Albee, Perng Ming-Der

Abstract excerpt

IF (intermediate filament) proteins can be cleaved by caspases to generate proapoptotic fragments as shown for desmin. These fragments can also cause filament aggregation. The hypothesis is that disease-causing mutations in IF proteins and their subsequent characteristic histopathological aggregates could involve caspases. GFAP (glial fibrillary acidic protein), a closely related IF protein expressed mainly in...

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Identifiers

PMID: 24102621
DOI: 10.1042/AN20130032
PMCID: PMC3833455

Genes

GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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