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Article

Elevated GFAP isoform expression promotes protein aggregation and compromises astrocyte function.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 May 2021

Lin Ni-Hsuan, Yang Ai-Wen, Chang Chih-Hsuan, Perng Ming-Der

Abstract excerpt

Alexander disease (AxD) caused by mutations in the coding region of GFAP is a neurodegenerative disease characterized by astrocyte dysfunction, GFAP aggregation, and Rosenthal fiber accumulation. Although how GFAP mutations cause disease is not fully understood, Rosenthal fibers could be induced by forced overexpression of human GFAP and this could be lethal in mice implicate that an increase in GFAP levels is...

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Identifiers

PMID: 33908669
DOI: 10.1096/fj.202100087R

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Elevated GFAP isoform expression promotes protein aggregation and compromises astrocyte function.PMID 33908669Read ↗

Glial fibrillary acidic protein is pathologically modified in Alexander disease.Semantic proximity Read ↗

Glial fibrillary acidic protein filaments can tolerate the incorporation of assembly-compromised GFAP-delta, but with consequences for filament organization and alphaB-crystallin association.Semantic proximity Read ↗

Synergistic Effects of Glial Fibrillary Acidic Protein Mutation and Overexpression in the Pathogenesis of Alexander Disease.Semantic proximity Read ↗

Cellular Models for Studying Alexander Disease: Functional Analysis of Primary Rat Astrocytes.Semantic proximity Read ↗

Phenotypic conversions of "protoplasmic" to "reactive" astrocytes in Alexander disease.Semantic proximity Read ↗

Murine model of Alexander disease: analysis of GFAP aggregate formation and its pathological significance.Semantic proximity Read ↗

Suppression of GFAP toxicity by alphaB-crystallin in mouse models of Alexander disease.Semantic proximity Read ↗

Experimental Approaches for Biochemical Analysis of Glial Fibrillary Acidic Protein and Its Disease-associated Variants.Semantic proximity Read ↗

Alexander-disease mutation of GFAP causes filament disorganization and decreased solubility of GFAP.Semantic proximity Read ↗

Properties of astrocytes cultured from GFAP over-expressing and GFAP mutant mice.Semantic proximity Read ↗

Effects of Alexander disease-associated mutations on the assembly and organization of GFAP intermediate filaments.Semantic proximity Read ↗

Aggregation-prone GFAP mutation in Alexander disease validated using a zebrafish model.Semantic proximity Read ↗

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