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Article

Alexander-disease mutation of GFAP causes filament disorganization and decreased solubility of GFAP.

Journal of cell science - 1 May 2005

Hsiao Victoria C, Tian Rujin, Long Heather, Der Perng Ming, Brenner Michael, Quinlan Roy A, Goldman James E

Abstract excerpt

Alexander disease is a fatal neurological illness characterized by white-matter degeneration and the formation of astrocytic cytoplasmic inclusions called Rosenthal fibers, which contain the intermediate filament glial fibrillary acidic protein (GFAP), the small heat-shock proteins HSP27 and alph...

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Identifiers

PMID: 15840648
DOI: 10.1242/jcs.02339

Genes

GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15840648-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Alexander-disease mutation of GFAP causes filament disorganization and decreased solubility of GFAP.PMID 15840648Read ↗

Alexander disease causing mutations in the C-terminal domain of GFAP are deleterious both to assembly and network formation with the potential to both activate caspase 3 and decrease cell viability.Semantic proximity Read ↗

Effects of Alexander disease-associated mutations on the assembly and organization of GFAP intermediate filaments.Semantic proximity Read ↗

Solid state NMR characterization of wild-type and mutant GFAP intermediate filament assembliesSemantic proximity Read ↗

Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease.Semantic proximity Read ↗

Elevated GFAP isoform expression promotes protein aggregation and compromises astrocyte function.Semantic proximity Read ↗

Glial fibrillary acidic protein filaments can tolerate the incorporation of assembly-compromised GFAP-delta, but with consequences for filament organization and alphaB-crystallin association.Semantic proximity Read ↗

Dynamics of mutated GFAP aggregates revealed by real-time imaging of an astrocyte model of Alexander disease.Semantic proximity Read ↗

GFAP and its role in Alexander disease.Semantic proximity Read ↗

Alexander disease: models, mechanisms, and medicine.Semantic proximity Read ↗

Murine model of Alexander disease: analysis of GFAP aggregate formation and its pathological significance.Semantic proximity Read ↗

Properties of astrocytes cultured from GFAP over-expressing and GFAP mutant mice.Semantic proximity Read ↗

GFAP mutations in Alexander disease.Semantic proximity Read ↗

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