Article

Characterization of Calpain and Caspase-6 Generated Glial Fibrillary Acidic Protein Breakdown Products Following Traumatic Brain Injury and Astroglial Cell Injury

2022-06-22

Abstract excerpt

Glial fibrillary acidic protein (GFAP) is the major intermediate filament III protein of astroglia cells which is upregulated in traumatic brain injury (TBI). Here we reported that GFAP is truncated at both the C- and N-terminals by cytosolic protease calpain to GFAP breakdown products (GBDP) of 46-40K then 38K following pro-necrotic (A23187) and pro-apoptotic (staurosporine) challenges to primary cultured astrogl...

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Literature Corpus work: ac327e38-98d1-5ea7-ba50-3c75ad72ff78
DOI: 10.20944/preprints202206.0310.v1

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