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Article

Plectin regulates the organization of glial fibrillary acidic protein in Alexander disease.

The American journal of pathology - 1 Mar 2006

Tian Rujin, Gregor Martin, Wiche Gerhard, Goldman James E

Abstract excerpt

Alexander disease (AxD) is a rare but fatal neurological disorder caused by mutations in the astrocyte-specific intermediate filament protein glial fibrillary acidic protein (GFAP). Histologically, AxD is characterized by cytoplasmic inclusion bodies called Rosenthal fibers (RFs), which contain GFAP, small heat shock proteins, and other undefined components. Here, we describe the expression of the cytoskeletal...

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Source

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Identifiers

PMID: 16507904
DOI: 10.2353/ajpath.2006.051028
PMCID: PMC1606531

Genes

GFAP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Plectin regulates the organization of glial fibrillary acidic protein in Alexander disease.PMID 16507904Read ↗

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The origin of Rosenthal fibers and their contributions to astrocyte pathology in Alexander diseaseSemantic proximity Read ↗

Plectin in the Central Nervous System and a Putative Role in Brain AstrocytesSemantic proximity Read ↗

Alexander-disease mutation of GFAP causes filament disorganization and decreased solubility of GFAP.Semantic proximity Read ↗

Murine model of Alexander disease: analysis of GFAP aggregate formation and its pathological significance.Semantic proximity Read ↗

Oligomers of mutant glial fibrillary acidic protein (GFAP) Inhibit the proteasome system in alexander disease astrocytes, and the small heat shock protein alphaB-crystallin reverses the inhibition.Semantic proximity Read ↗

Clinical aspects and pathology of Alexander disease, and morphological and functional alteration of astrocytes induced by GFAP mutation.Semantic proximity Read ↗

Effects of Alexander disease-associated mutations on the assembly and organization of GFAP intermediate filaments.Semantic proximity Read ↗

Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease.Semantic proximity Read ↗

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